个人简介
李建，1982年6月生，博士，教授，硕士研究生导师。2007年至2014年先后于美国俄亥俄大学和耶鲁大学攻读博士学位及开展博士后研究工作，2015年回国加入成都大学。 作为项目主持人获得国家自然科学基金，四川省高层次人才计划项目，人力资源社会保障部“留学回国人员科技活动择优资助”，四川省科技厅国际合作项目，四川省自然科学基金等项目资助，在包括Molecular Cell, Blood, PNAS等国际著名学术期刊发表论文30余篇，入选四川省人才计划项目及四川省学术与技术带头人后备人选。
科研项目
1. 国家自然科学基金：波棱甲素抗肝纤维化直接作用靶点发现及分子机制研究 （批准号：82473804), 49万，2025－2028，主持
2. 四川省自然科学基金，基于TRPV1通路的卷叶贝母再生鳞茎镇咳药效物质基础研究（批准号：2022NSFSC0583)，20万，2021-2023，主持
3. 西南特色中药资源国家重点实验室开放基金，波棱瓜子缓解酒精性肝损伤的分子机制研究（批准号：SCMR202103), 10万，2021－2023，主持
4. 国家自然科学基金：DNA聚合酶zeta（Pol z）维持基因组稳定性的机制研究 （批准号：31500657), 24万，2016－2018，主持
5. 四川省人才计划项目, 50万，2017-2019, 主持
6. 人力资源社会保障部“留学回国人员科技活动择优资助”优秀类项目, DNA聚合酶zeta导致癌症化疗耐药产生的机制研究，24万，2016-2018, 主持
7. 四川省科技厅国际合作项目：基于合成致死效应的肾癌靶向药物研发（批准号：2017HH0097），20万， 2017-2019，主持
8. 成都大学引进人才科研启动项目，DNA损伤修复与人类重大疾病的关联性研究，100万，2015-2018，主持
研究方向
1. 具有生物学活性的天然产物的发现与功能研究；
2.重组蛋白/多肽的分子设计，功能及应用研究。
代表论文
1.Feng Zhao, Yixi Yang, Wenyao Zhan, Zhiqi Li, Hui Yin, Jingjing Deng, Waner Li, Rui Li, Qi Zhao, Jian Li* (2024) Engineering the bacteriophage 80 alpha endolysin as a fast and ultrasensitive detection toolbox against Staphylococcus aureus. Biosensors and Bioelectronics. 266:116727 (中科院1区，影响因子:10.700，通讯作者)
2.Jiaqing Liao, Qiuxia Lu, Zhiqi Li, Jintao Li, Qi Zhao, Jian Li* (2023) Acetaminophen-induced liver injury: molecular mechanism and treatments from natural products. Front Pharmacol. 14:773 (中科院2区，影响因子:5.195，通讯作者)
3.Jintao Li, Qiuxia Lu, Meihao Peng, Jiaqing Liao, Bowen Zhang, Di Yang, Peng Huang, Yixi Yang, Qi Zhao, Bo Han, Jian Li* (2022) Water extract from Herpetospermum pedunculosum attenuates oxidative stress and ferroptosis induced by acetaminophen via regulating Nrf2 and NF-κB pathways. J Ethnopharmacol. 305:116069 (中科院2区，影响因子:5.195，通讯作者)
4.Xi Lin, Liyan Guo, Sheng Lin, Zimin Chen, Fanli Yang, Jing Yang, Lingling Wang, Ao Wen, Yanping Duan, Xindan Zhang, Yushan Dai, Keqing Yin, Xin Yuan, Chongzhang Yu, Bin He, Yu Cao, Haohao Dong, Jian Li, Qi Zhao, Guangwen Lu (2022) An engineered 5-helix bundle derived from SARS-CoV-2 S2 pre-binds sarbecoviral spike at both serological-and endosomal-pH to inhibit virus entry. Emerging Microbes & Infections. 11(1):1920-1935. (中科院1区，影响因子:19.568)
5.Guangwen Lu, Jing Yang, Sheng Lin, Honglu Sun, Zimin Chen, Fanli Yang, Xi Lin, Liyan Guo, Lingling Wang, Ao Wen, Xindan Zhang, Yushan Dai, Bin He, Yu Cao, Haohao Dong, Xianbo Liu, Bo Chen, Jian Li, Qi Zhao (2022) A potent neutralizing nanobody targeting the spike receptor-binding domain of SARS-CoV-2 and the structural basis of its intimate binding. Frontiers in immunology. 13: 820336. (中科院2区，影响因子:8.786)
6.Qiuxia Lu, Rui Li, Yixi Yang, Yujin Zhang, Qi Zhao, Jian Li* (2021) Ingredients with anti-inflammatory effect from medicine food homology plants. Food Chemistry . P130610 (中科院1区，影响因子: 9.231，通讯作者)
7.Qianye Yang, Yu Li, Rong Sun, Jian Li* (2021) Identification of a RAD52 inhibitor inducing synthetic lethality in BRCA2 deficient cancer cells. Front Pharmacol. 12(939) (中科院2区，影响因子: 5.988，通讯作者)
8.Kejia Huang, Rong Sun, Jiarong Chen, Qianye Yang, Yucheng Wang, Yang Zhang, Kun Xie, Tiantian Zhang, Rui Li, Qi Zhao, Liang Zou*, Jian Li* (2020) A Novel Ezh2 Inhibitor Induces Synthetic Lethality and Apoptosis in Pbrm1-Deficient Cancer Cells. Cell Cycle, 19(7): p. 758-71. (中科院3区，影响因子: 5.173)
9.Yu Deng*, Wanjun Guo, Ning Xu, Fulun Li and Jian Li (2020) CtBP1 transactivates RAD51 and confers cisplatin resistance to breast cancer cells. Mol Carcinog, 59(5): p. 512-519. (中科院2区，影响因子: 5.139)
10.Jian Li, Wenwen Li, Kejia Huang, Yang Zhang, Gary Kupfer, Qi Zhao* (2018) Chimeric Antigen Receptor T cell (CAR-T) immunotherapy for solid tumors: lessons learned and strategies for moving forward, J Hematol Oncol. 11 (1), 22 (中科院1区，影响因子：23.168, ESI 高被引论文)
11.Pierre Billon, Jian Li, Jean-Philippe Lambert, Yizhang Chen, Véronique Tremblay, Joseph S. Brunzelle, Anne-Claude Gingras, Alain Verreault, Tomohiko Sugiyama, Jean-Francois Couture, Jacques Côté* (2017) Acetylation of PCNA Sliding Surface by Eco1 Promotes Genome Stability through Homologous Recombination. Molecular Cell. 65(1):78-90 (中科院1区，影响因子：19.328)
12.Jian Li*, Nan Zhou, Peiling Cai, and Jinku Bao* (2016) In Silico Screening Identifies a Novel Potential PARP1 Inhibitor Targeting Synthetic Lethality in Cancer Treatment. Int. J. Mol. Sci.17, 258. (中科院2区，影响因子：6.208)
13.Simonne Longerich, Jian Li, Yong Xiong, Patrick Sung, Gary M Kupfer* (2014) Stress and DNA repair biology of the fanconi anemia pathway, Blood.124(18):2812-9 (中科院1区，影响因子：25.476)
14.Jian Li, Donald Holzschu, and Tomihiko Sugiyama* (2013) PCNA is efficiently loaded on the DNA recombination intermediate to modulate DNA polymerase δ, η, and ζ activities. Proc Natl Acad Sci USA. 110, 7672–7677 (中科院1区，影响因子：12.779)
15.Wenwen Li, Jian Li, and Jinku Bao* (2012) Microautophagy: lesser-known self-eating, Cell Mol Life Sci. 69, 1125-36 (中科院2区，影响因子：9.207)
