报告题目：基于全氟烷基化-脱氟策略的新型含氟结构单元合成新方法 (A Perfluoroalkylation-Defluorination Strategy for Accessing Emerging Fluorinated Motifs)
报告人：Prof. 徐哲 (Chit Tsui (Gavin)); 香港中文大学 (The Chinese University of Hong Kong)
报告时间：2026年11月03日10:30-11:30 (邀请人：明佳林)
报告地点：中国–东盟艺术学院 A 栋 A1018 学术报告厅（东盟小礼堂）
报告内容简介：目前，尽管已有多种全氟烷基化方法可用于将含氟基团引入有机分子，但现有研究多集中于三氟甲基化反应。另一方面，通过选择性断裂全氟分子中的 C-F 键并实现其官能团化，可进一步制备具有独特性能优势的部分氟化化合物。本报告将介绍我们课题组近期在全氟烷基化 – 脱氟策略应用于新型含氟分子合成方面的研究进展。研究表明，通过依次实施全氟烷基化与脱氟官能团化，可高效、高选择性地构建一系列结构新颖的氟化砌块，该策略为复杂氟化结构的精准合成提供了有效途径。
Although various perfluoroalkylation methods are currently available for incorporating fluorine-containing groups into organic molecules, existing studies have largely focused on trifluoromethylation. In contrast, the selective cleavage of C–F bonds in perfluorinated molecules followed by functionalization can further enable the preparation of partially fluorinated compounds with unique property advantages. This presentation will introduce our group’s recent progress in the application of perfluoroalkylation–defluorination strategies to the synthesis of novel fluorinated molecules. Our studies demonstrate that the sequential implementation of perfluoroalkylation and defluorinative functionalization enables the efficient and highly selective construction of a range of structurally novel fluorinated building blocks. This strategy provides an effective route for the precise synthesis of complex fluorinated structures.
