单位：成都大学基础医学院   川藏特色药用植物资源开发利用四川省高校工程研究中心

通讯地址：成都市成洛大道2025号

邮箱：lijian01@cdu.edu.cn

李建，1982年6月出生，博士，教授，现任成都大学基础医学院副院长。2013年在美国俄亥俄大学获得博士学位，随后在耶鲁大学从事博士后研究。2015年回国任成都大学医学院特聘研究员。2016入选四川省特聘专家，2018入选四川省学术和技术带头人后备人选。现担任中国生物工程学会青年工作委员会委员；四川省生物化学与分子生物学会理事；四川省侨联特聘专家，四川省侨联青年工作委员会委员，成都市侨联青年工作委员会副会长。已发表包括PNAS，Molecular cell，Blood，Journal of Hematology and Oncology等高水平研究论文30余篇，获得国家自然科学基金，人社部“留学回国人员科技活动择优资助”，四川省科技厅国际合作项目等资助。

主要研究方向

DNA损伤修复的生物化学机制及其与疾病的关联性；

具有生物学活性的天然产物的发现与功能研究；

重组蛋白/多肽的分子设计，功能及应用研究。

代表论文

1. Jiaqing Liao, Qiuxia Lu, Zhiqi Li, Jintao Li, Qi Zhao and Jian Li* (2023) Acetaminophen-induced liver injury: molecular mechanism and treatments from natural products. Front Pharmacol. DOI: 10.3389/fphar.2023.1122632 (中科院 2 区，影响因子: 5.988，通讯作者)

2. Jintao Li, Qiuxia Lu, Meihao Peng, Jiaqing Liao, Bowen Zhang, Di Yang, Peng Huang, Yixi Yang, Qi Zhao, Bo Han, Jian Li* (2022) Water extract from Herpetospermum pedunculosum attenuates oxidative stress and ferroptosis induced by acetaminophen via regulating Nrf2 and NF-κB pathways. J Ethnopharmacol. 305:116069 (中科院 2 区，影响因子:5.195，通讯作者)

3. Xi Lin, Liyan Guo, Sheng Lin, Zimin Chen, Fanli Yang, Jing Yang, Lingling Wang, Ao Wen, Yanping Duan, Xindan Zhang, Yushan Dai, Keqing Yin, Xin Yuan, Chongzhang Yu, Bin He, Yu Cao, Haohao Dong, Jian Li, Qi Zhao, Guangwen Lu (2022) An engineered 5-helix bundle derived from SARS- CoV-2 S2 pre-binds sarbecoviral spike at both serological-and endosomal-pH to inhibit virus entry. Emerging Microbes & Infections. 11(1):1920-1935. (中科院 1 区，影响因子:19.568)

4. Guangwen Lu, Jing Yang, Sheng Lin, Honglu Sun, Zimin Chen, Fanli Yang, Xi Lin, Liyan Guo, Lingling Wang, Ao Wen, Xindan Zhang, Yushan Dai, Bin He, Yu Cao, Haohao Dong, Xianbo Liu, Bo Chen, Jian Li, Qi Zhao (2022) A potent neutralizing nanobody targeting the spike receptor-binding domain of SARS-CoV-2 and the structural basis of its intimate binding. Frontiers in immunology. 13: 820336. (中科院 2 区，影响因子:8.786)

5. Qiuxia Lu, Rui Li, Jiaqing Liao, Yuqin Hu, Yundong Gao, Mingcheng Wang, Jian Li*, Qi Zhao* (2022) Integrative analysis of the steroidal alkaloids distribution and biosynthesis of bulbs Fritillariae Cirrhosae through metabolome and transcriptome analyses. BMC Genomics . 23(1): 1-12 (中科院 2 区，影响因子: 4.547，通讯作者)

6. Qiuxia Lu, Rui Li, Yixi Yang, Yujin Zhang, Qi Zhao, Jian Li* (2021) Ingredients with anti- inflammatory effect from medicine food homology plants. Food Chemistry . P130610 (中科院 1 区， 影响因子: 9.231，通讯作者)

7. Qianye Yang, Yu Li, Rong Sun, Jian Li* (2021) Identification of a RAD52 inhibitor inducing synthetic lethality in BRCA2 deficient cancer cells. Front Pharmacol. 12(939) (中科院 2 区，影响因子: 5.988，通讯作者)

8. Kejia Huang, Rong Sun, Jiarong Chen, Qianye Yang, Yucheng Wang, Yang Zhang, Kun Xie, Tiantian Zhang, Rui Li, Qi Zhao, Liang Zou*, Jian Li* (2020) A Novel Ezh2 Inhibitor Induces Synthetic Lethality and Apoptosis in Pbrm1-Deficient Cancer Cells. Cell Cycle, 19(7): p. 758-71. (中科院 3 区， 影响因子: 5.173)

9. Yu Deng*, Wanjun Guo, Ning Xu, Fulun Li and Jian Li (2020) CtBP1 transactivates RAD51 and confers cisplatin resistance to breast cancer cells. Mol Carcinog, 59(5): p. 512-519. (中科院 2 区， 影响因子: 5.139)

10. Rui Li, Yang Zhang, Yucheng Wang, Kejia Huang, Qianye Yang, Tiantian Zhang, Kun Xie, Jian Li* and Qi Zhao* (2020) Aqueous extract of Fritillariae cirrhosae induces cellular apoptosis through activation of STATs-mediated immunomodulation. J Ethnopharmacol. 261:112338 (中科院 2 区， 影响因子:5.195，通讯作者)

11. Shasha Xing, Jian Yang, Wenjing Li, Jian Li, Lin Chen, Yuting Yang, Xia Lei, Jun Li, Kai Wang and Xun Liu*(2020)Salidroside Decreases Atherosclerosis Plaque Formation via Inhibiting Endothelial Cell Pyroptosis. Inflammation, 43(2): p. 433-440. (中科院 3 区，影响因子:4.657)

12. Liang Zou, Xiaowei Liu, Jingjing Li, Wei Li, Lele Zhang, Jian Li*, Jinming Zhang* (2019) Tetramethylpyrazine Enhances the Antitumor Effect of Paclitaxel by Inhibiting Angiogenesis and Inducing Apoptosis, Front Pharmacol. 10:707 （中科院 2 区，影响因子:5.988，通讯作者）

13. Jian Li, Wenwen Li, Kejia Huang, Yang Zhang, Gary Kupfer, Qi Zhao* (2018) Chimeric Antigen Receptor T cell (CAR-T) immunotherapy for solid tumors: lessons learned and strategies for moving forward, J Hematol Oncol. 11 (1), 22 (中科院 1 区，影响因子：23.168, ESI 高被引论文)

14. Jian Li, Qianye Yang, Yang Zhang, Kejia Huang, Rong Sun, Qi Zhao* (2018) Compound F779-0434 causes synthetic lethality in BRCA2-deficient cancer cells by disrupting RAD52–ssDNA association, RSC Advances, 8, 18859-18869 (中科院 3 区，影响因子：4.036)

15. Qi Zhao, Rui Li, Yang Zhang, Kejia Huang, Wenguo Wang, Jian Li* (2018)Transcriptome analysis reveals in vitro-cultured regeneration bulbs as a promising source for targeted Fritillaria cirrhosa steroidal alkaloid biosynthesis, 3 Biotech, 8 (4), 191(中科院 4 区，影响因子：2.893，通讯作者)

16. Sha-Sha Xing, Jian Li, Lin Chen, Yafei Yang, Ping-Lin He, Jun Li, Jin Yang* (2018) Salidroside attenuates endothelial cellular senescence via decreasing the expression of inflammatory cytokines and increasing the expression of SIRT3, Mech Ageing Dev. 175, 1-6 (中科院 2 区，影响因子：5.498)

17. Jun Li, and Jian Li* (2017) Can A Longer Waiting Period After Neoadjuvant Chemoradiotherapy Improve the Pathologic Complete Response Rate in Patients With Rectal Cancer?, J Clin Oncol. DOI: 10.1200/JCO.2016.69.7318 (中科院 1 区, 影响因子：50.717，通讯作者)

18. Jian Li #, Rong Sun#, Yuehong Wu, Minngzhu Song, Jia Li, Qianye Yang, Xiaoyi Chen, Jinku Bao*, Qi Zhao* (2017) L1198F mutation resensitizes crizotinib to ALK by altering the conformation of inhibitor and ATP binding sites, Int. J. Mol. Sci, 18(3), 482 (中科院 2 区，影响因子：6.208)

19. Pierre Billon, Jian Li, Jean-Philippe Lambert, Yizhang Chen, Véronique Tremblay, Joseph S. Brunzelle, Anne-Claude Gingras, Alain Verreault, Tomohiko Sugiyama, Jean-Francois Couture, Jacques Côté* (2017) Acetylation of PCNA Sliding Surface by Eco1 Promotes Genome Stability through Homologous Recombination. Molecular Cell. 65(1):78-90 (中科院 1 区，影响因子：19.328)

20. Jian Li*, Nan Zhou, Peiling Cai, and Jinku Bao* (2016) In Silico Screening Identifies a Novel Potential PARP1 Inhibitor Targeting Synthetic Lethality in Cancer Treatment. Int. J. Mol. Sci.17, 258.

(中科院 2 区，影响因子：6.208)

21. Simonne Longerich, Jian Li, Yong Xiong, Patrick Sung, Gary M Kupfer* (2014) Stress and DNA repair biology of the fanconi anemia pathway, Blood.124(18):2812-9 (中科院 1 区，影响因子： 25.476)

22. Jian Li, Donald Holzschu, and Tomihiko Sugiyama* (2013) PCNA is efficiently loaded on the DNA recombination intermediate to modulate DNA polymerase δ, η, and ζ activities. Proc Natl Acad Sci USA. 110, 7672–7677 (中科院 1 区，影响因子：12.779)

23. Wenwen Li, Jian Li, and Jinku Bao* (2012) Microautophagy: lesser-known self-eating, Cell Mol Life Sci. 69, 1125-36 (中科院 2 区，影响因子：9.207)

24. Yang Yu, Yuan Deng, Bang-min Lu, Yong-xi Liu, Jian Li*, Jin-ku Bao* (2013) Green tea catechins: a fresh flavor to anticancer therapy. Apoptosis. 1-18 (中科院 2 区, 影响因子：5.561)

25. Chuan-Fang Wu#, Jian Li#, Jie An, Li-Qing Chang, Fang Chen, Jin-Ku Bao* (2006) Purification, Biological Activities, and Molecular Cloning of a Novel Mannose-Binding Lectin from Bulbs of Zephyranthes candida Herb (Amaryllidaceae). J Int Plant Biol, 48, 223-231 (中科院 1 区，影响因子：9.106)

科研项目

1. 四川省自然科学基金，基于 TRPV1 通路的卷叶贝母再生鳞茎镇咳药效物质基础研究（批准号：2022NSFSC0583)，20 万，2021-2023，主持

2. 西南特色中药资源国家重点实验室开放基金，波棱瓜子缓解酒精性肝损伤的分子机制研究（批准号：SCMR202103), 10 万， 2021－2023，主持

2. 国家自然科学基金：DNA 聚合酶 zeta（Pol z）维持基因组稳定性的机制研究

（批准号：31500657), 24 万， 2016－2018，主持

3. 四川省千人计划青年人才项目, 50 万，2017-2019, 主持

4. 人力资源社会保障部“留学回国人员科技活动择优资助”优秀类项目, DNA 聚合酶

zeta 导致癌症化疗耐药产生的机制研究，24 万，2016-2018, 主持

5. 四川省科技厅国际合作项目：基于合成致死效应的肾癌靶向药物研发（批准号：

2017HH0097），20 万， 2017-2019，主持

6. 成都大学引进人才科研启动项目，DNA 损伤修复与人类重大疾病的关联性研究，100 万，2015-2018，主持